Gene knockdown of CENPA reduces sphere forming ability and stemness of glioblastoma initiating cells
نویسندگان
چکیده
a Department of Molecular Medicine, Institute of Basic Medical Sciences, The Medical Faculty, University of Oslo, Oslo, Norway b Norwegian Center for Stem Cell Research, Department of Immunology and Transfusion Medicine, Oslo University Hospital, Oslo, Norway c Vilhelm Magnus Laboratory for Neurosurgical Research, Institute for Surgical Research and Department of Neurosurgery, Oslo University Hospital, Oslo, Norway
منابع مشابه
The embryonic type of SPP1 transcriptional regulation is re-activated in glioblastoma
Osteopontin (SPP1, a secreted phosphoprotein 1) is primarily involved in immune responses, tissue remodelling and biomineralization. However, it is also overexpressed in many cancers and regulates tumour progression by increasing migration, invasion and cancer stem cell self-renewal. Mechanisms of SPP1 overexpression in gliomas are poorly understood. We demonstrate overexpression of two out of ...
متن کاملDownregulation of lncRNA-HOXA11-AS modulates proliferation and stemness in Glioma cells
Background: Glioma stem cells (GSCs) represent a subpopulation of cells within glioma that are characterized by chemotherapy resistance and tumor recurrence. GSCs are therefore important therapeutic target for glioma therapy. Long non-coding RNAs (lncRNAs) have been shown to regulate important functions in cancer. HOXA11-AS is one such lncRNA and has been shown to regulate cell proliferation vi...
متن کاملHeat Shock Factor 1 Depletion Sensitizes A172 Glioblastoma Cells to Temozolomide via Suppression of Cancer Stem Cell-Like Properties
Heat shock factor 1 (HSF1), a transcription factor activated by various stressors, regulates proliferation and apoptosis by inducing expression of target genes, such as heat shock proteins and Bcl-2 (B-cell lymphoma 2) interacting cell death suppressor (BIS). HSF1 also directly interacts with BIS, although it is still unclear whether this interaction is critical in the regulation of glioblastom...
متن کاملبررسی اثر مهاری سیلیبینین بر رشد و خواص بنیادینگی مامواسفیرهای حاصل از سلولهای رده MCF-7
Introduction: The cancer stem cells are the small population of cells in tumor tissue with the ability of self-renew and differentiation into other tumor cells. Targeting these cells has great importance in the treatment of cancer and prevent cancer recurrence. Milk thistle is the plant of the Asteraceae with the scientific name of Silybum Marianum. However there is no report about the effect o...
متن کاملβ-escin selectively targets the glioblastoma-initiating cell population and reduces cell viability
Glioblastoma multiforme (GBM) is a highly aggressive tumour of the central nervous system and is associated with an extremely poor prognosis. Within GBM exists a subpopulation of cells, glioblastoma-initiating cells (GIC), which possess the characteristics of progenitor cells, have the ability to initiate tumour growth and resist to current treatment strategies. We aimed at identifying novel sp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Neuroepigenetics
دوره 7 شماره
صفحات -
تاریخ انتشار 2016